• The HPV cause of head and neck cancers: epidemiology, burden and new developments

• Keynote lecture: HPV-associated cancers - a growing problem?

• HPV and oropharyngeal cancer: current knowledge

• Current management of head & neck cancer

• The role of papillomavirus infection in skin cancer development

• HPV, oesophagus & lung: what evidence?

• The significance of HPV in the colon & rectum

SEMINAR ON HPV AND HEAD & NECK CANCER

Seminar 1: HPV and head & neck cancer

• The burden of head & neck cancer and the changing risk factors

• The epidemiology and burden of HPV-oropharyngeal cancer

• Molecular carcinogenesis of HPV+ve and HPV-ve head and neck cancer

• Effect of HPV on survival in head & neck cancer

• The epidemiology of oral HPV infection, the transmission issue and what it means for the patient and their spouse

• The potential value of screening & vaccination

• Biological correlates of HPV positivity in cervical and oropharyngeal HPV tumors

• Prognostic factors of HPV positive cases and serological markers in follow-up

• The challenges of prospective research in oropharyngeal cancer

• Therapeutic vaccination in HPV head & neck cancer – fact or fiction?

a. Surgical treatment options for oropharyngeal cancer (Open surgery and transoral laser or robotic surgery)

b. Chemoradiotherapy

a. Setting up a diagnostic service for HPV – head & neck cancer

b. Pitfalls in the diagnosis of HPV in head & neck cancer

For

Against

• Similarities and differences in the epidemiology of HPV infection (cervical vs. oral)

• Similarities and differences in the epidemiology of cancer

• Similarities and differences between cancer of the cervix and the upper aerodigestive tract

• Mechanisms of carcinogenesis

• What HPV types should be considered high-risk/oncogenic? Type-specificity of cancer risk

• Clinical value of testing for HPV infection and additional markers

• Potential for primary and secondary prevention through HPV vaccination and screening

• Incidence and risk factors for head and neck cancer and cervical cancer among HIV-infected individuals in North America

• HPV serology and head & neck cancers: new evidence

• Differences in the epidemiology and risk factors of HPV+ and HPV-ve head and neck cancers

• Differences between HPV+ve and HPV-ve head and neck cancers at the molecular level

• Are we encountering an HPV epidemic of OSCC – the Stockholm – data

• Treatments for HPV+ vs HPV-ve disease – should they be different?

• Molecular biology of HPV-associated HNSCC

• Incidence of HPV induced oropharyngeal cancer in Spain and its prognostic significance

• HLA class I expression and tumor infiltrating CD8+ and FoxP3+ T-cells in HPV+/- tonsillar cancer in relation to disease free survival

• Is HPV16 detection in cervical lymph nodes of oropharyngeal cancer a marker of metastases?

• Demographic differences in the prevalence of oral HPV in U.S. adults; cross sectional analysis of NHANES 2009-2010

• HPV status alters the miRNA expression in tonsillar cancer

• Comparative miRNA profiling in human papilloma virus related head & neck and cervical cancer

• Validation of a novel diagnostic standard in HPV positive oropharyngeal squamous cell carcinoma

• HPV detection by PCR in suspected tonsillar lesions: smear-biopsy agreement

• Oral mucosa exfoliated cells for HPV typing by SPF10 in head and neck cancer

• Human papillomavirus infection and p16^INK4a/Ki-67 co-expression in the head and neck squamous epithelium

• HPV/p16^INK4a status in squamous cell carcinomas of the oral cavity

• HPV infection in squamous cell carcinomas arising from different mucosal sites of the head and neck region. Different significance of p16 immunohistochemistry

• HPV genotyping in head & neck squamous cell carcinoma (HNSCC) and pre-neoplastic oral lesions (OPL) by SPF10 LiPA assay

• Prognostic factors including role of HPV in early oropharyngeal carcinomas

• HPV prevalence and relation to tobacco and alcohol in HNSCC in North-East Italy