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HPV and Anal Diseases Forum

Toward an integrated system for secondary prevention and treatment of anal cancer

Wednesday, February 10
9.00 - 18.30

The incidence of anal cancer is increasing in many countries around the world particularly among individuals over 50 years of age.

Primary prevention of anal cancer is accomplished through HPV vaccination of individuals before exposure to the HPV types that cause anal cancer. Secondary prevention is accomplished through detection and treatment of the anal cancer precursor, anal high-grade squamous intraepithelial lesions (HSIL). 

We now know that treatment of anal HSIL can reduce the incidence of anal cancer, similar to the reduction in cervical cancer associated with detection and treatment of cervical HSIL. Secondary prevention of anal cancer is a much younger field than prevention of cervical cancer, and virtually all elements of a secondary anal cancer prevention program require further development and optimization of current approaches.

In addition, further work is needed to better integrate the wide range of health care delivery systems and health care professions involved in the various steps involved, including screening, referral for high resolution anoscopy (HRA), biopsy of visible HSIL, treatment of HSIL and follow-up after treatment. Other professional interactions are key as well, including close collaboration with pathologists, proctologists/colorectal surgeons, radiation oncologists and medical oncologists.

This session will explore how each of the steps in the screening and treatment process can be improved on, including adoption of new technologies, and how the various entities described above can be better integrated to ensure a smoother, more efficient experience for patients.

9.00 - 10.00

I. Screening for anal high-grade squamous intraepithelial lesions (HSIL) and anal cancer

Chair
Joel Palefsky
USA

10.30 - 11.30

II. Treatment of anal high grade squamous intraepithelial lesions (HSIL)

Chair
Joel Palefsky
USA

11.30 - 12.30

III. Treatment of anal cancer

Chair

Joel Palefsky
USA

15.00 - 16.30

IV. Current advances in anal disease management

This workshop will address emerging developments and challenges in HPV-related anal disease management, including the use of methylation and other biomarkers for clinical decision-making, optimization of HRA training across the world, screening needs and strategies for low-risk populations, and the implications of vaccination and need for long-term follow-up. Each topic will include dedicated time for interactive discussion. We aim on bringing together current evidence, clinical experience and areas of uncertainty to explore how anal cancer prevention and disease management strategies can be further refined and implemented in clinical practice.

Chair

Stephen E. Goldstone
USA
Renske Steenbergen
Netherlands

17.00 - 18.30

V. Drivers of global anal cancer incidence – HPV, HIV, screening and classification

Anal cancer risk is caused by HPV infection, with significantly elevated rates in people with HIV and notable sex differences. Prior work has suggested that roughly 1 in 4 of anal squamous cell carcinomas among people without HIV and 2 in 7 among people with HIV were diagnosed in the U.S. in 2020, despite the U.S. including <5% of the world’s population. The objective of the session will be to describe anal HPV infection, HIV prevalence, screening and diagnosis in relation to anal cancer incidence. We will introduce the session with an overview of global data, and then each speaker will describe the existing epidemiology of each established driver of anal cancer incidence and provide a regional context for observed incidence rates. We will end the session with a moderated panel discussion and then open a Q&A to the audience.

Chair

Cameron Haas
USA
Meredith Shiels
USA

Register today

Don't miss out on the the world’s leading international congress on HPV infection and associated cancers.
See you in Bologna, February 10-13, 2027.